Trophic and neurotrophic factors in human pituitary adenomas (Review)
نویسندگان
چکیده
منابع مشابه
Pituitary adenomas: a review
Pituitary adenomas, as the majority of pituitary neoplasms, are typically benign, slow-growing tumors that arise from cells in the pituitary gland. Those are classified based on secretory products. The functioning (endocrine-active) tumors include almost 70% of pituitary tumors which produce 1 or 2 hormones that are measurable in the serum and cause definite clinical syndromes, that are classif...
متن کاملINVITED COMMENTARY Growth factors and human pituitary adenomas
In recent years, the demonstration that human pituitary adenomas are monoclonal provides further support for the existence of genomic mutations occurring in the progenitor cell that subsequently undergoes clonal expansion. All the molecules that physiologically control pituitary cell differentiation and growth may be potentially oncogenic as they may become the target of mutations or be altered...
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MicroRNAs (miRNAs) are a class of recently identified noncoding RNAs that regulate gene expression at posttranscriptional level. Due to the large number of genes regulated by miRNAs, miRNAs play important roles in many cellular processes. Emerging evidence indicates that miRNAs are dysregulated in pituitary adenomas, a class of intracranial neoplasms which account for 10-15% of diagnosed brain ...
متن کاملMicroscopic Transsphenoidal Surgery for Pituitary Adenomas in Children and Adolescents
Background & Aim: We described the presentation, management and subsequent treatment outcomes of children and adolescents diagnosed with a pituitary adenoma in a joint neuroendocrine setting followed up by a single service as well as assessing long-term outcomes in terms of endocrine status and neurology symptoms. Methods & Materials/Patients: A total of 21 participants with histologically v...
متن کاملTreatment of Pituitary Carcinomas and Atypical Pituitary Adenomas: A Review
Atypical pituitary adenomas (APAs) are aggressive tumors, harboring a Ki-67 (MIB-1) staining index of 3% or more, and positive immunohistochemical staining for p53 protein, according to the World Health Organization (WHO) classification in 2004. Pituitary carcinomas (PC) usually develop from progressive APAs and predominantly consist of hormone-generating tumors, defined by the presence of diss...
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ژورنال
عنوان ژورنال: International Journal of Oncology
سال: 2017
ISSN: 1019-6439,1791-2423
DOI: 10.3892/ijo.2017.4120